You can use I think 8 inputs simultaneously…so you can ADD BUS 3 times, which gives you a total of 8 inputs. You should see all the inputs from the Zoom device. There click the INPUTS tab and click the cell for LEFT IN under DEVICE PORT. From there go to DEVICES tab then to VST CONNECTION. From there apply your changes and close that box. Click on VST AUDIO SYSTEM in the left side, and under the VST AUDIO SYSTEM in the right side click the ASIO device that you will use…in this case, your Zoom R16 device. From there you will need to go to the DEVICE SETUP. Everything you will need to do is under the DEVICE menu. I assume you have already downloaded and installed the device drivers. If you have more questions shoot me an email. Cubase LE 4 will allow you to use 4 of these at once fro a total of 32 Simultaneous tracks with about 6 milliseconds of latency. Hope I helped and btw, if you like recording simultaneously, take a look at M-Audio 1010LT. When you add an audio track select the input to whatever you are recording from, and to do 8 tracks simultaneously, just add 8 tracks and select a different input for each input and arm every track to record. You can rename the names of the inputs to whatever you would like. From there just click the DEVICE PORT for that input and select the corresponding input.